What is the most abundant extracellular cation? What hormone controls extracellular fluid volume?Īldosterone is a major regulator of extracellular fluid volume and the principal determinant of potassium metabolism 1, 2, 3, 4, 5. Under normal circumstances, wide variations in salt intake lead to parallel changes in renal salt excretion, such that ECF volume is maintained within narrow limits. Extracellular fluid (ECF) volume is determined by the balance between sodium intake and renal excretion of sodium. The extracellular fluids may be divided into three types: interstitial fluid in the “interstitial compartment” (surrounding tissue cells and bathing them in a solution of nutrients and other chemicals), blood plasma and lymph in the “intravascular compartment” (inside the blood vessels and lymphatic vessels), and small … What affects ECF volume? (ICF is 2/3 of TBW, i.e., 40% of body weight ECF is 1/3 of TBW, i.e., 20% of body weight.) What are the three types of extracellular fluid? Approximately 60% of body weight is water (TBW), 40% of body weight is ICF, and 20% is ECF. How do you calculate ECF volume?Ī simple tool is the 60-40-20 rule. Expansion of the ECF generally means expansion of the blood volume, and contraction of the ECF volume generally means contraction of the blood volume. Thus blood comprises about 36% of the ECF volume. What is ECF volume expansion?īlood volume is typically about 5 L, whereas ECF volume is about 14 L. This is accomplished primarily though alterations in sodium and water reabsorption, the mechanisms of which differ within each nephron segment. The kidneys, in concert with neural and endocrine input, regulate the volume and osmolality of the extracellular fluid by altering the amount of sodium and water excreted.
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